Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats
Identifieur interne : 000231 ( Main/Exploration ); précédent : 000230; suivant : 000232Effects of Cobalt on Membrane ATPases, Oxidant, and Antioxidant Values in the Cerebrum and Cerebellum of Suckling Rats
Auteurs : Elmouldi Garoui [Tunisie] ; Ibtissem Ben Amara [Tunisie] ; Dorra Driss [Tunisie] ; Awatef Elwej [Tunisie] ; Semia Ellouze Chaabouni [Tunisie] ; Tahia Boudawara [Tunisie] ; Najiba Zeghal [Tunisie]Source :
- Biological Trace Element Research [ 0163-4984 ] ; 2013.
Descripteurs français
- KwdFr :
- Acetylcholinesterase (métabolisme), Adenosine triphosphatases (métabolisme), Administration par voie orale, Animaux, Animaux allaités, Antioxydants (métabolisme), Attribution aléatoire, Butyrylcholine esterase (métabolisme), Carbonylation des protéines (), Catalase (métabolisme), Cerveau (), Cerveau (anatomopathologie), Cerveau (métabolisme), Cervelet (), Cervelet (anatomopathologie), Cervelet (métabolisme), Cobalt (administration et posologie), Cobalt (sang), Cobalt (toxicité), Effets différés de l'exposition prénatale aux facteurs de risque (), Effets différés de l'exposition prénatale aux facteurs de risque (métabolisme), Femelle, Fragmentation de l'ADN (), Glutathione peroxidase (métabolisme), Grossesse, Malonaldéhyde (métabolisme), Oxydants (métabolisme), Peroxyde d'hydrogène (métabolisme), Produits d'oxydation avancée des protéines (métabolisme), Protéines liées au GPI (métabolisme), Rat Wistar, Rats, Superoxide dismutase (métabolisme).
- MESH :
- administration et posologie : Cobalt.
- anatomopathologie : Cerveau, Cervelet.
- métabolisme : Acetylcholinesterase, Adenosine triphosphatases, Antioxydants, Butyrylcholine esterase, Catalase, Cerveau, Cervelet, Effets différés de l'exposition prénatale aux facteurs de risque, Glutathione peroxidase, Malonaldéhyde, Oxydants, Peroxyde d'hydrogène, Produits d'oxydation avancée des protéines, Protéines liées au GPI, Superoxide dismutase.
- sang : Cobalt.
- toxicité : Cobalt.
- Administration par voie orale, Animaux, Animaux allaités, Attribution aléatoire, Carbonylation des protéines, Cerveau, Cervelet, Effets différés de l'exposition prénatale aux facteurs de risque, Femelle, Fragmentation de l'ADN, Grossesse, Rat Wistar, Rats.
English descriptors
- KwdEn :
- Acetylcholinesterase (metabolism), Adenosine Triphosphatases (metabolism), Administration, Oral, Advanced Oxidation Protein Products (metabolism), Animals, Animals, Suckling, Antioxidants (metabolism), Butyrylcholinesterase (metabolism), Catalase (metabolism), Cerebellum (drug effects), Cerebellum (metabolism), Cerebellum (pathology), Cerebrum (drug effects), Cerebrum (metabolism), Cerebrum (pathology), Cobalt (administration & dosage), Cobalt (blood), Cobalt (toxicity), DNA Fragmentation (drug effects), Female, GPI-Linked Proteins (metabolism), Glutathione Peroxidase (metabolism), Hydrogen Peroxide (metabolism), Malondialdehyde (metabolism), Oxidants (metabolism), Pregnancy, Prenatal Exposure Delayed Effects (chemically induced), Prenatal Exposure Delayed Effects (metabolism), Protein Carbonylation (drug effects), Random Allocation, Rats, Rats, Wistar, Superoxide Dismutase (metabolism).
- MESH :
- chemical , administration & dosage : Cobalt.
- chemical , blood : Cobalt.
- chemical , metabolism : Acetylcholinesterase, Adenosine Triphosphatases, Advanced Oxidation Protein Products, Antioxidants, Butyrylcholinesterase, Catalase, GPI-Linked Proteins, Glutathione Peroxidase, Hydrogen Peroxide, Malondialdehyde, Oxidants, Superoxide Dismutase.
- chemically induced : Prenatal Exposure Delayed Effects.
- drug effects : Cerebellum, Cerebrum, DNA Fragmentation, Protein Carbonylation.
- metabolism : Cerebellum, Cerebrum, Prenatal Exposure Delayed Effects.
- pathology : Cerebellum, Cerebrum.
- chemical , toxicity : Cobalt.
- Administration, Oral, Animals, Animals, Suckling, Female, Pregnancy, Random Allocation, Rats, Rats, Wistar.
Abstract
Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls. Exposure to Co also increased the levels of MDA, PCO, H2O2, and AOPP, while Na+K+-ATPase and Mg2+-ATPase, AChE, and BuChE activities decreased in the cerebrum and cerebellum of suckling pups. A smear without ladder formation on agarose gel was also shown in the cerebrum and cerebellum, indicating random DNA degradation. A reduction in GPx, SOD, CAT, GSH, NPSH, and vitamin C values was observed. The changes were confirmed by histological results. In conclusion, these data showed that the exposure of pregnant and lactating rats to Co resulted in the development of oxidative stress and the impairment of defense systems in the cerebrum and cerebellum of their suckling pups.
Url:
DOI: 10.1007/s12011-013-9746-0
PubMed: 23857379
PubMed Central: 3744383
Affiliations:
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Cerebellum of Suckling Rats</title><author><name sortKey="Garoui, Elmouldi" sort="Garoui, Elmouldi" uniqKey="Garoui E" first="Elmouldi" last="Garoui">Elmouldi Garoui</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Amara, Ibtissem Ben" sort="Amara, Ibtissem Ben" uniqKey="Amara I" first="Ibtissem Ben" last="Amara">Ibtissem Ben Amara</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Driss, Dorra" sort="Driss, Dorra" uniqKey="Driss D" first="Dorra" last="Driss">Dorra Driss</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax</wicri:regionArea><wicri:noRegion>3038 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Elwej, Awatef" sort="Elwej, Awatef" uniqKey="Elwej A" first="Awatef" last="Elwej">Awatef Elwej</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Chaabouni, Semia Ellouze" sort="Chaabouni, Semia Ellouze" uniqKey="Chaabouni S" first="Semia Ellouze" last="Chaabouni">Semia Ellouze Chaabouni</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Enzymes and Bioconversions Laboratory, National Engineering School, University of Sfax, BP 1173, 3038 Sfax</wicri:regionArea><wicri:noRegion>3038 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Anatomopathology Laboratory, CHU Habib Bourguiba, University of Sfax, 3029 Sfax</wicri:regionArea><wicri:noRegion>3029 Sfax</wicri:noRegion></affiliation></author><author><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax, Tunisia</nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Animal Physiology Laboratory, Life Sciences Department, Sfax Faculty of Sciences, University of Sfax, BP 1171, 3000 Sfax</wicri:regionArea><wicri:noRegion>3000 Sfax</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biological Trace Element Research</title><idno type="ISSN">0163-4984</idno><idno type="eISSN">1559-0720</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholinesterase (metabolism)</term><term>Adenosine Triphosphatases (metabolism)</term><term>Administration, Oral</term><term>Advanced Oxidation Protein Products (metabolism)</term><term>Animals</term><term>Animals, Suckling</term><term>Antioxidants (metabolism)</term><term>Butyrylcholinesterase (metabolism)</term><term>Catalase (metabolism)</term><term>Cerebellum (drug effects)</term><term>Cerebellum (metabolism)</term><term>Cerebellum (pathology)</term><term>Cerebrum (drug effects)</term><term>Cerebrum (metabolism)</term><term>Cerebrum (pathology)</term><term>Cobalt (administration & dosage)</term><term>Cobalt (blood)</term><term>Cobalt (toxicity)</term><term>DNA Fragmentation (drug effects)</term><term>Female</term><term>GPI-Linked Proteins (metabolism)</term><term>Glutathione Peroxidase (metabolism)</term><term>Hydrogen Peroxide (metabolism)</term><term>Malondialdehyde (metabolism)</term><term>Oxidants (metabolism)</term><term>Pregnancy</term><term>Prenatal Exposure Delayed Effects (chemically induced)</term><term>Prenatal Exposure Delayed Effects (metabolism)</term><term>Protein Carbonylation (drug effects)</term><term>Random Allocation</term><term>Rats</term><term>Rats, Wistar</term><term>Superoxide Dismutase (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Acetylcholinesterase (métabolisme)</term><term>Adenosine triphosphatases (métabolisme)</term><term>Administration par voie orale</term><term>Animaux</term><term>Animaux allaités</term><term>Antioxydants (métabolisme)</term><term>Attribution aléatoire</term><term>Butyrylcholine esterase (métabolisme)</term><term>Carbonylation des protéines ()</term><term>Catalase (métabolisme)</term><term>Cerveau ()</term><term>Cerveau (anatomopathologie)</term><term>Cerveau (métabolisme)</term><term>Cervelet ()</term><term>Cervelet (anatomopathologie)</term><term>Cervelet (métabolisme)</term><term>Cobalt (administration et posologie)</term><term>Cobalt (sang)</term><term>Cobalt (toxicité)</term><term>Effets différés de l'exposition prénatale aux facteurs de risque ()</term><term>Effets différés de l'exposition prénatale aux facteurs de risque (métabolisme)</term><term>Femelle</term><term>Fragmentation de l'ADN ()</term><term>Glutathione peroxidase (métabolisme)</term><term>Grossesse</term><term>Malonaldéhyde (métabolisme)</term><term>Oxydants (métabolisme)</term><term>Peroxyde d'hydrogène (métabolisme)</term><term>Produits d'oxydation avancée des protéines (métabolisme)</term><term>Protéines liées au GPI (métabolisme)</term><term>Rat Wistar</term><term>Rats</term><term>Superoxide dismutase (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Cobalt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Cobalt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Acetylcholinesterase</term><term>Adenosine Triphosphatases</term><term>Advanced Oxidation Protein Products</term><term>Antioxidants</term><term>Butyrylcholinesterase</term><term>Catalase</term><term>GPI-Linked Proteins</term><term>Glutathione Peroxidase</term><term>Hydrogen Peroxide</term><term>Malondialdehyde</term><term>Oxidants</term><term>Superoxide Dismutase</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Cobalt</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Cerveau</term><term>Cervelet</term></keywords><keywords scheme="MESH" qualifier="chemically induced" xml:lang="en"><term>Prenatal Exposure Delayed Effects</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebellum</term><term>Cerebrum</term><term>DNA Fragmentation</term><term>Protein Carbonylation</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cerebellum</term><term>Cerebrum</term><term>Prenatal Exposure Delayed Effects</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Acetylcholinesterase</term><term>Adenosine triphosphatases</term><term>Antioxydants</term><term>Butyrylcholine esterase</term><term>Catalase</term><term>Cerveau</term><term>Cervelet</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Glutathione peroxidase</term><term>Malonaldéhyde</term><term>Oxydants</term><term>Peroxyde d'hydrogène</term><term>Produits d'oxydation avancée des protéines</term><term>Protéines liées au GPI</term><term>Superoxide dismutase</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebellum</term><term>Cerebrum</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Cobalt</term></keywords><keywords scheme="MESH" type="chemical" qualifier="toxicity" xml:lang="en"><term>Cobalt</term></keywords><keywords scheme="MESH" qualifier="toxicité" xml:lang="fr"><term>Cobalt</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Animals</term><term>Animals, Suckling</term><term>Female</term><term>Pregnancy</term><term>Random Allocation</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Animaux</term><term>Animaux allaités</term><term>Attribution aléatoire</term><term>Carbonylation des protéines</term><term>Cerveau</term><term>Cervelet</term><term>Effets différés de l'exposition prénatale aux facteurs de risque</term><term>Femelle</term><term>Fragmentation de l'ADN</term><term>Grossesse</term><term>Rat Wistar</term><term>Rats</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Chronic overexposure to cobalt (Co) may result in neurotoxic effects, but the mechanism of Co-induced neurotoxicity is not yet well established. Our study was conducted to determine whether Co is associated to the induction of central nervous system damage in pregnant rats and their progeny. Twelve pregnant female rats were randomly divided into 2 groups: group I served as controls and group II received Co (350 mg/L, orally). Treatments started from the 14th day of pregnancy until day 14 after delivery. Co concentration in plasma was higher in the treated groups than in the controls. Exposure to Co also increased the levels of MDA, PCO, H<sub>2</sub>O<sub>2</sub>, and AOPP, while Na<sup>+</sup>K<sup>+</sup>-ATPase and Mg<sup>2+</sup>-ATPase, AChE, and BuChE activities decreased in the cerebrum and cerebellum of suckling pups. A smear without ladder formation on agarose gel was also shown in the cerebrum and cerebellum, indicating random DNA degradation. A reduction in GPx, SOD, CAT, GSH, NPSH, and vitamin C values was observed. The changes were confirmed by histological results. In conclusion, these data showed that the exposure of pregnant and lactating rats to Co resulted in the development of oxidative stress and the impairment of defense systems in the cerebrum and cerebellum of their suckling pups.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Gault, N" uniqKey="Gault N">N Gault</name></author><author><name sortKey="Sandre, C" uniqKey="Sandre C">C Sandre</name></author><author><name sortKey="Poncy, Jl" uniqKey="Poncy J">JL Poncy</name></author><author><name sortKey="Moulin, C" uniqKey="Moulin C">C Moulin</name></author><author><name sortKey="Lefaix, Jl" uniqKey="Lefaix J">JL Lefaix</name></author><author><name sortKey="Bresson, C" uniqKey="Bresson C">C Bresson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karovic, O" uniqKey="Karovic O">O Karovic</name></author><author><name sortKey="Tonazzini, I" uniqKey="Tonazzini I">I Tonazzini</name></author><author><name 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Karihtala</name></author><author><name sortKey="Soini, Y" uniqKey="Soini Y">Y Soini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Sharaky, As" uniqKey="El Sharaky A">AS El-Sharaky</name></author><author><name sortKey="Newairy, Aa" uniqKey="Newairy A">AA Newairy</name></author><author><name sortKey="Badreldeen, Mm" uniqKey="Badreldeen M">MM Badreldeen</name></author><author><name sortKey="Eweda, Sm" uniqKey="Eweda S">SM Eweda</name></author><author><name sortKey="Sheweita, Sa" uniqKey="Sheweita S">SA Sheweita</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hasebe, M" uniqKey="Hasebe M">M Hasebe</name></author><author><name sortKey="Matsumoto, I" uniqKey="Matsumoto I">I Matsumoto</name></author><author><name sortKey="Imagawa, T" uniqKey="Imagawa T">T Imagawa</name></author><author><name sortKey="Uehara, M" uniqKey="Uehara M">M Uehara</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farwell, Ap" uniqKey="Farwell A">AP Farwell</name></author><author><name sortKey="Dubord Tomasettia, Sa" uniqKey="Dubord Tomasettia S">SA Dubord-Tomasettia</name></author><author><name sortKey="Pietrzykowskia, Az" uniqKey="Pietrzykowskia A">AZ Pietrzykowskia</name></author><author><name sortKey="Stachelek, Sj" uniqKey="Stachelek S">SJ Stachelek</name></author><author><name sortKey="Leonard, Jl" uniqKey="Leonard J">JL Leonard</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><country name="Tunisie"><noRegion><name sortKey="Garoui, Elmouldi" sort="Garoui, Elmouldi" uniqKey="Garoui E" first="Elmouldi" last="Garoui">Elmouldi Garoui</name></noRegion><name sortKey="Amara, Ibtissem Ben" sort="Amara, Ibtissem Ben" uniqKey="Amara I" first="Ibtissem Ben" last="Amara">Ibtissem Ben Amara</name><name sortKey="Boudawara, Tahia" sort="Boudawara, Tahia" uniqKey="Boudawara T" first="Tahia" last="Boudawara">Tahia Boudawara</name><name sortKey="Chaabouni, Semia Ellouze" sort="Chaabouni, Semia Ellouze" uniqKey="Chaabouni S" first="Semia Ellouze" last="Chaabouni">Semia Ellouze Chaabouni</name><name sortKey="Driss, Dorra" sort="Driss, Dorra" uniqKey="Driss D" first="Dorra" last="Driss">Dorra Driss</name><name sortKey="Elwej, Awatef" sort="Elwej, Awatef" uniqKey="Elwej A" first="Awatef" last="Elwej">Awatef Elwej</name><name sortKey="Zeghal, Najiba" sort="Zeghal, Najiba" uniqKey="Zeghal N" first="Najiba" last="Zeghal">Najiba Zeghal</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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